5000IU of vitamin D

Vitamin D has Anti-Inflammatory Role

Studies have shown potent effects of vitamin D on both innate and adaptive immunity.

It has the potential to influence a wide range of immune disorders, particularly infectious and autoimmune diseases (RR2R3).

Cells involved in innate and adaptive immune responses (macrophages, dendritic cells, T cells and B cells) express the vitamin D receptor and synthesize the active vitamin D byproduct (RR2).

Effects of vitamin D on immune system include:

  • Inhibits B cell production, and antibody secretion (RR2)
  • Decreases T cell growth, inhibits T cell activation and IL-2 production (RR2)
  • Results in a shift from a Th1 to a Th2 phenotype (RR2)
  • Regulates the activity of monocytes/macrophages (RR2)
  • Inhibits dendritic cells production and growth (RR2)
  • Decreases the secretion of inflammatory cytokines IL-1, IL-2, IL-6, IL-8, IL-17, TNF-α, IFN-γ, and IL-12 (RR2R3R4)
  • Increases cytokines IL-10 and IL-4 (RR2R3R4)
  • Inhibits production of IgE by B cells and enhances production of IL-10 by dendritic cells and T cells, playing an important role in allergic immune responses (RR2)
  • Reduces the expression of MHC class II, CD40, CD80, and CD86 (RR2)
  • Decreases TGF-beta (contributes to tissue repair by promoting tissue fibrosis) (RR2R3, R4)
  • Crucial for T Cell activation (R)
  • Regulates differentiation of CD4+ T cells (decreases Th1 and Th17 cell production, and increases Th2 and Treg cell production) (RR2)
  • Increases CD8+ T  Cells, important in controlling viruses, intracellular bacteria, and cancer (RR2)
  • Increases Natural Killer T Cells (R)
  • Releases antimicrobials in response to an infection such as cathelicidin and beta defensin 4 (RR2)

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