A lot of the information given below is derived from animal and laboratory-based studies. Human studies are still falling behind, but will hopefully soon follow.
1) Sulforaphane Promotes Detoxification
Sulforaphane is an indirect antioxidant. It boosts the antioxidant capacity of cells by at least two mechanisms (R).:
- Inducing phase 2 detoxification enzymes – Sulforaphane is the most potent inducer of phase 2 enzymes identified to date. It acts by activating Nrf2 and ARE (R, R, R), and increasing glutathione S-transferases activity (R).
- Increasing cellular glutathione levels
2) Sulforaphane Prevents and Combats Cancer
Of all the molecules I’ve studied, sulforaphane and broccoli sprouts are the most promising at preventing and killing cancer (R).
The great thing about sulforaphane is that it kills cancer cells, but seems to have very little effect on healthy cells (R).
Sulforaphane treatment reduce DNA damage and mutation rate when cancer-causing chemicals bind DNA (R).
Sulforaphane kills colorectal cancer cells (R), oral squamous cell carcinoma cells (R), breast cancer cells (R), cervical cancer cells, liver cancer cells, prostate cancer cells and leukemia cells (R, R).
Sulforaphane combats cancer by multiple mechanisms:
- SFN inhibits Phase I enzymes that can activate pro-carcinogens (R).
- SFN induces Phase II enzymes that are responsible for eliminating chemicals that damage DNA (R).
- SFN changes gene activation/deactivation (R). It causes demethylation, thereby restoring the activity of important tumor-suppressing and cell-cycle controlling genes (R).
- Sulforaphane induces cancer cell death (R).
- Sulforaphane inhibits the NF-κB pathway, thus reducing inflammation(R).
- Sulforaphane induces cell cycle arrest (R) and thereby inhibits cancer cell proliferation.